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In addition, CDNs can be exported outside the cells and may act systemically to induce an antiviral state throughout the body

HH is characterized by mutations of the HFE gene, involved in the hepcidin/ferroportin axis, which results in insufficient hepcidin production or, exceptionally, in hepcidin resistance
This can reduce its potency or render it completely inactive, which would invalidate your research data

They play a crucial role in the regulation of synaptic networks by modulating neurotransmitter release at the presynaptic sites and by participating in membrane depolarization at postsynapses 4