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15,16 Although PD is commonly associated with motor symptoms, some non-motor symptoms, such as olfactory dysfunction and dream re-enactment behavior, can present before the onset of the classic motor symptoms of PD, whereas others manifest at later stages, such as cognitive decline and neuropsychiatric disorders

As a result, you start to feel more tired because the mitochondria are less efficient when they get oxidized or rusted. The free radical damage caused by oxidation then triggers your immune system to clean up the damage, which results in inflammation

[DOI] [PMC free article] [PubMed] [Google Scholar] 215.Shah A., et al

PMID 6316150