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However, because OSC reactivity can lead to off-target thiol modification, clinical development requires careful concentrationresponse optimization and, for less stable compounds such as allicin analogues, formulation or localized delivery strategies
Consequently, the precise control of excessive inflammation while simultaneously promoting its resolution remains a major challenge in advancing ARDS treatment
Dobrowolski P
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These findings elucidate the critical role of ER stress-generated LTC 4 in triggering NOX4-mediated oxidative DNA damage following ER stress
