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FIGURE 4 3.2.2 Carcinogenic effects of ROS ROS accumulation exhibits dual cytotoxic/mutagenic effects, mediating tumorigenesis and cell death

231 found accelerated DNA methylation age in Down syndrome patients with clinical signatures of accelerated ageing. There is also evidence that frailty, a syndrome with a pronounced association with age-related phenotypes, has a significant association with DNA methylation age, but not with telomere length

C., Ge J., Fu H., Miao L., Zhao F., Wang J

Paradoxically, oxygen as a molecule which sustains aerobic life, against being essential for energy metabolism and respiration, is involved within the mechanism of the onset of various diseases and degenerative conditions (Sies et al., 2017)