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Additionally, a previously studied liver-specific deletion of Gclc was shown to cause steatohepatitis and liver failure 30

Conversely, another viewpoint posits that a decrease in serum selenium leads to reduced levels of GPX in the body, weakening antioxidant capacity, enhancing lipid peroxidation, and ultimately damaging pancreatic -cells, thereby triggering diabetes

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GSH is synthesized ( de novo ) from amino acids by the sequential action of g-glutamylcysteine synthetase ( glutamate cysteine ligase ) and glutathione synthetase (Alscher and Hess, 1993) and the de-novo GSH synthesis is required for the elevation of GSH levels as an adaptive response to oxidative stress (Nimse and Pal, 2015)