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Abbreviations CEBPB CCAAT/enhancer-binding protein beta LAP1 Liver-enriched activator protein 1 LIP Liver-enriched inhibitory protein ESCC Esophageal squamous cell carcinoma EMT Epithelial-mesenchymal transition MDSCs Myeloid-derived suppressor cells AFP Alpha-fetoprotein-producing GC Gastric cancer FAO Fatty acid oxidation ROS Reactive oxygen species NGAL Neutrophil gelatinase-associated lipocalin SphK1 Sphingosine kinase 1 CSCs Cancer stem cells FXR Farnesoid X receptor CRC Colorectal cancer Tregs Regulatory T cells ER Endoplasmic reticulum TTA Tetradecylthioacetic acid PDAC Pancreatic ductal adenocarcinoma CCNG1 Cyclin G1 HCC Hepatocellular carcinoma eIF6 Eukaryotic initiation factor 6 GADD45A DNA damage 45 alpha PRCA Prostate cancer CRPC Castration-resistant prostate cancer ADT Androgen deprivation therapy AR Androgen receptor RCC Renal cell carcinoma TAMs Tumor-associated macrophages MMPs Matrix metalloproteinases BLCA Bladder cancer BRCA Breast cancer TNBC Triple-negative breast cancer PA Palmitic acid OC Ovarian Cancer EGF Epidermal growth factor CC Cervical cancer ceRNA Competing endogenous RNA TC Thyroid cancer OSCC Oral squamous cell carcinoma HNSCC Head and neck squamous cell carcinoma EIF3B Eukaryotic translation initiation factor 3 subunit B NPC Nasopharyngeal carcinoma NSCLC Non-small cell lung cancer LC Lung cancer ISG15 Interferon-stimulated gene 15 ACC Adenoid cystic carcinoma LAP Lysophosphatidic acid CLL Chronic lymphocytic leukemia miRNAs microRNAs lncRNAs Long non-coding RNAs circRNAs Circular RNAs Author contributions ABH and CJW contributed to manuscript draft and figure drawing, ABH, YZ and DX: critical revision of the manuscript for important intellectual content, administrative support, obtaining funding, supervision

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