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True as this may be, chronic FOXO4 reduction is not advisable as FOXOs play a role in DNA-damage repair and Foxo4/ mice are susceptible to acute damage(Zhou et al., 2009)
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Its use should be limited to research applications, and any consideration of peptide therapy should be conducted under professional supervision, with a thorough evaluation of potential risks and benefits
However, further studies are necessary before the regulation of barrier permeability can be introduced into clinical practice 104
