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Safety Concerns Therapeutic peptides are generally considered safe with low immunogenicity and a favorable adverse effect profile compared with many pharmacologic agents

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It can directly increase the longevity of mRNA and protein levels of Sirt1 and FOXO1 and decrease the expression of NF-B, acetyl-CoA carboxylase, and fatty acid synthase (Yuan et al., 2020)

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Engineered bacteria, such as nanoparticle-modified E.coli , can promote the polarization of M2 macrophages into the M1 phenotype and activate innate immune responses in vivo, thereby enhancing antitumor immunity [185]

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