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Other supplements, especially hormonally active botanicals such as chasteberry, and blood-thinning supplements such as high-dose omega-3 and vitamin E, are commonly paused around treatment

Abbreviations AMPK: AMP-dependent protein kinase Bcl-2: B-cell lymphoma-2 Bax: Bcl2-Associated X CDK2: Cyclin-dependent kinases 2 C10:2: Decadienyl-l-carnitine ETO: Etomoxir HSP47: Heat shock protein 47 IL-1: Interleukin-1 IL-18: Interleukin-18 MCT: Monocrotaline MMP2: Matrix metallopeptidase 2 MMP9: Matrix metallopeptidase 9 NLRP3: NOD-,LRR-and pyrin domain-containing protein 3 PASMCs: Pulmonary artery smooth muscle cells PCNA: Proliferating cell nuclear antigen PDGF-BB: Platelet-derived growth factor-BB PH: Pulmonary hypertension PVR: Pulmonary vascular remodeling ROS: Reactive oxygen species TGF-: Transforming growth factor References Ruopp NF, Cockrill BA

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

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