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DOI: 10.1016/j.ijheh.2016.11.012

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[7] Drugs or toxins that have a pharmacological (type A) hepatotoxicity are those that have predictable dose-response curves (higher concentrations cause more liver damage) and well characterized mechanisms of toxicity, such as directly damaging liver tissue or blocking a metabolic process

Immunostaining results revealed a notable increase in the expression of the histone variant H2AX, which is a known marker for DNA double-strand breaks (DSBs)