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They key indicator is an imabalance in the anti-oxidant mechanisms existing with (reduced/oxidized) glutathione
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Exogenous Glutamate Concentration Regulates the Metabolic Fate of Glutamate in Astrocytes. Journal of Neurochemistry 66: 386393
On the basis of the GPS database ( TXNDC5 has four ubiquitination sites, including K118, K143, K150, and K244
