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The total number of the cells was evaluated based on the following formula: where Q was the total number of sexual lineage cells observed in all disectors, h was the optical disector's height, a/f was the area of the counting frame, P was the total number of observed frames, BA was the setting of the microtome, and t was the mean of the final section thickness [36]

Combination of hyper-CVAD with ponatinib as first-line therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia: a single-centre, phase 2 study

doi: 10.1159/000213266

Mongersen exhibited good efficacy and safety for the treatment of CD in one phase 1 and three phase 2 clinical trials [155,156,157,158], but its development was suspended due to a lack of efficacy in phase 3 clinical trials