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Description
Therefore, we proposed that the decrease in GPx1 caused by glucose deprivation leads to further ROS-dependent autophagy activation

doi: 10.1210/jc.2009-2611

Yet, most remain at proof-of-concept or early preclinical stages, with limited scalability, regulatory clarity, and long-term safety validation

Overall, AOD-9604 appears safe, with a profile similar to a placebo
