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It is a direct blockade of one of the primary engines driving chronic inflammatory states
Mechanical strain-induced extracellular matrix production by human vascular smooth muscle cells: role of TGF-1

doi: 10.1300/J092v14n02_04 35 Falk HvidbergMBrinthLSOlesenAVPetersenKDEhlersL

Then, in the 70s, that number increased to once every two months
