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Instead of the classical CXXC-motif present in Trx family members, DUF1094 proteins contain an invariant CGC active site, and likely use a monothiol mechanism to reduce S -bacillithiolated cysteines [52,207]

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Other studies have previously indicated that tirzepatide alone facilitates greater relative weight loss compared to semaglutide monotherapy, a trend that appears to persist even when semaglutide is paired with an amylin analog