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H 2 S is produced in various tissues and plays a significant role in the circulatory system homeostasis, including the heart, blood vessels, and kidneys [95]

Alternatively, preclinical studies using leptin-deficient animals ( ob/ob mice) demonstrated that restoring plasma leptin concentration to normal improved heart function after MI, and that these beneficial effects were associated with reductions in cardiac inflammation and apoptosis [13, 14] and activation of anti-hypertrophic pathways in obese animals with left ventricle (LV) hypertrophy [8]

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Transplant Proc 2005