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Low Vitamin B12 and Lipid Metabolism: Evidence from Pre-Clinical and Clinical Studies

Tablets were dissolved in water before oral ingestion or administration though the nasoenteral tube ( The study participants and the assisting infectious disease physicians were aware of the treatments, except laboratory team which performed the clinical laboratory and the immunoassays presented in the present study, to whom the study was blinded ( All study participants underwent a baseline evaluation, which included physical examination, sputum (spontaneous or induced whenever sputum production was considered insufficient) or tracheal aspirate in unconscious patients, CD4+ T-lymphocyte count, HIV viral load, serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubins, and screening of concomitant drug exposures and chest radiograph, as previously described ( Respiratory samples were submitted to smear ZiehlNielsen staining technique, Xpert-Mtb/RIF for Mtb, and sown in liquid culture BACTEC MGIT 960 and solid culture Lwenstein-Jensen as previously described ( Laboratory Measurements Serum samples were used to measure total oxidant status, total antioxidant status and glutathione levels

Pathophysiology of alpha- and beta-Thalassemia: Therapeutic Implications