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Usually, B12 is absorbed once it is attached to the protein intrinsic factor (IF), made by cells in the stomach

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Unsubstantiated marketing of B 12 supplements often claim that their clinical effects depend on the B 12 form(s) they contain, and some claims have promoted the marketing of certain forms of supplemental B 12 , including that supplemental MeCbl may be superior to other forms in supporting intracellular methylation reactions, that supplemental AdCbl may be better at increasing intramitochondrial levels of AdCbl, or that supplemental OHCbl may result in lower levels of S -adenosylmethionine (SAMe) than supplemental MeCbl

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