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doi: 10.1074/jbc.M301872200

Disorders Associated with Tetrahydrobiopterin Synthesis and Salvage There are at least four identified disorders that manifest with BH 4 -deficient hyperphenylalaninemia designated as hyperphenylalaninemia, BH 4 -deficient type A (HPABH4A), HPABH4B, HPABH4C, and HPABH4D

For example, in Escherichia coli O157:H7 (Figure 6A), the interactions between -PL and phospholipid groups result in distorting and shriveling of the cell membrane in a non-specific, carpet-like mechanism, in which the membrane is forced to fold in on itself, contributing to vesicle/micelle and toroidal pore formation (Hyldgaard et al., 2014)