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Current knowledge highlights a disturbed mitochondrial function in immune cells for various immunological diseases [570]

Rather than causing a frank decrease in complex III function, this mutation appears to result in delayed assembly of the I,III,IV supercomplex, 43 thus influencing the interaction of complex III with other complexes rather than specifically affecting only complex III

PUFA-PLs are synthesized from PUFA through the sequential action of acyl-coenzyme A (CoA) synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase3 (LPCAT3)