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Lymphocyte-deficient RAG (-/-) mice, when previously primed with allogeneic spleen cells or skin grafts, exhibited monocyte-mediated alloimmunity, i.e., allogeneic spleen cells were recognized and removed (75)

In lupus-prone females, reduced abundance of Erysipelotrichaceae and Bifidobacterium, with increased Lachnospiraceae and Bacteroidetes S247 abundance, has also been reported ( These findings suggest that microbiological dysbioses specific to sex, more precisely the increased prevalence of Lachnospiraceae in females, may account for the earlier onset and greater severity of lupus symptoms

62 , 63 , 249 The recently adopted combination of the GFD-MedD pyramid avoids the harmful effects of gluten while adding the numerous benefits of the Mediterranean diet

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