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Western blots showed decreased expression of enzymes of GSH synthesis (catalytic subunit of glutamate cysteine ligase [GCLC], modifier subunit of GCL [GCLM], and glutathione synthetase [GSS]) indicating impaired GSH synthesis as a cause for GSH deficiency
Although the exact mechanism of ALS is unknown, recent studies underlined the significance of autophagy in misfolded proteins' clearance and suggested that impaired autophagy may be the basis for ALS onset [113]

10.1212/WNL.0b013e3181ff9685 Neurology 114 MortiboysH.ThomasK

Polyphenols One of the major sources of polyphenols is tea
