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Description
It was approved by EMA and FDA in 2012 (EMA, 2024b

The extensive heterogeneity and episodic nature of mitochondrial diseases, along with a lack of real-time biomarkers to evaluate disease severity, makes it difficult to measure day-to-day clinical response

These lesions are pale and evenly pigmented and may have a rounded or angulated shape

We quantified mildronate using its deuterated analog ([ 2 H]-mildronate) as an internal standard, while endogenous L-carnitine was relatively quantified using a surrogate matrix
