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Accumulation of itaconate occurs in the lungs of mice infected with Mycobacterium tuberculosis 92 and in macrophages activated with LPS 93

We hypothesized that in both strains, tpx1 and trx1 trx3 , H 2 O 2 scavenging may be compromised, and that enhanced basal peroxides could trigger OxyR oxidation

By optimizing the LNP surface structure and ligands, the study achieved efficient siRNA delivery and substantial KRAS silencing
