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Post-burn scars and scar contractures
Recombinant human insulin-like growth factor-I (rhIGF-I) therapy in adults with type 1 diabetes mellitus: effects on IGFs, IGF-binding proteins, glucose levels and insulin treatment

Anecdotal reports on forums and YouTube mention side effects like sagging skin, puffiness, or crepey texture, particularly when formulations are too strong or used too frequently
Handle tablets with clean laboratory gloves and tools to maintain integrity