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Gradogna et al
It did not take long before the pieces began to fall into place for Burnet in terms of how to improve Jerne's theory (figures 14a and 14b)

In studies on pain, increased secretion of gp130, IL-6, and IL-6R was found in the dorsal root ganglia and spinal cord, which has been associated with disease pathology.[23,24] However, the levels of IL-6 in the patient group were also higher than in the healthy group in the present study, and this increase was statistically significant

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