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Description
While the conventional paradigm is that of elevated systemic blood pressure leading to glomerular hyperfiltration and arteriolosclerosis, recent evidence has elucidated a much more intricate pathophysiological milieu with a wide range of hemodynamic, molecular, immunological, metabolic, and genetic factors

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This effect was not sensitive to naloxone, indicating a distinct mechanism from its opioid-mediated antinociceptive effects 8

There is no precise data on this ratio for humans