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GHK-Cu is the most well-characterized of the three in terms of extracellular matrix effects
Their activity results in the emergence of hydroperoxides of polyunsaturated fatty acids that are transformed into highly reactive bifunctional electrophiles hydroxynonenal and 4oxo-nonenal, which form crosslinks in proteins and DNA [28]
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During fasting, the metabolic shift from glycolysis to fatty acid oxidation reduces mitochondrial ROS generation, thereby improving redox homeostasis [66]
