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Description
Glutathione therapy: from prodrugs to genes

[DOI] [PubMed] [Google Scholar] 106.Cascinu S., Catalano V., Cordella L., Labianca R., Giordani P., Baldelli A.M., Beretta G.D., Ubiali E., Catalano G

Evidence (cardioprotective effect of dexrazoxane): In a DFCI ALL Consortium trial, children with high-risk ALL were randomly assigned to receive doxorubicin alone (30 mg/m2/dose to a cumulative dose of 300 mg/m2) or with dexrazoxane during the induction and intensification phases of multiagent chemotherapy.[87,88] The use of the cardioprotectant dexrazoxane before doxorubicin resulted in better left ventricular fractional shortening and improved end-systolic dimension Z-scores without any adverse effect on EFS or increase in second malignancy risk, compared with the use of doxorubicin alone 5 years posttreatment

[DOI] [PubMed] [Google Scholar] 56.Shah D, Kiran R, Wanchu A, Bhatnagar A
