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The LBD domains of distal subunits A/C move by ~9.7 while that for proximal B/D move by 21.6 for B and only 12.1 for subunit C, again highlighting the asymmetric arrangement of LBD in UBP310 bound state (Supplementary Movie 3)

Gene-Associated Pathways were identified using the Enrichment_rank of the pathways based on their statistical significance ( P values) of KEGG pathway enrichment analyses for AD-associated genes from different sources: Enrichment_rank_1 used AD-associated genes from Open Targets, and Enrichment_rank_2 used genetically associated AD genes identified in genome-wide association and familial studies

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