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Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFbeta interaction

It forms a stable covalent bond between the antibody and payload and does not rely on microenvironmental triggers for release

Expanding the m / z range over which the QIT can be used for mass analysis is desirable for the application of ion/ion reactions to large proteins and protein complexes
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