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No significant differences between treatment groups were observed using the Chao1 richness estimate 42 , which accounts for ASV rareness in the richness measure (Supplementary Fig
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3.3 Changes in serum cobalamin by supplementation route and dosage Across 35 comparisons, the mean percentage increase in serum cobalamin following supplementation was approximately 293%, confirming the overall effectiveness of vitamin B12 interventions (Supplementary Table S4)
