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Structural docking studies show that Cagrilintides hydrophobic residues interact favorably with the transmembrane domains of the CTR, enhancing receptor activation stability

[DOI] [PubMed] [Google Scholar] 63.Janda C.Y., Dang L.T., You C., Chang J., de Lau W., Zhong Z.A., Yan K.S., Marecic O., Siepe D., Li X., et al

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The REDEFINE 1 trial found that when evaluating the treatment effect regardless of whether patients stayed on treatment, those treated with CagriSema achieved weight loss of 20.4% (from an average baseline body weight of 236 lb) at 68 weeks versus 3.0% (from an average baseline body weight of 235 lb) for the placebo group which was statistically significant
