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Introduction Lactoferrin (LF), an ~80 kDa iron-binding glycoprotein present in most biological fluids (saliva, milk, tears, and mucous secretions), was first identified in 1939, and isolated and purified from human and bovine milk in 1960 ( 3+ ) ion ( Bacteriostatic effect of LF is attributed to the binding capacity with free iron, which is an essential element for the growth of bacteria ( Escherichia coli ( E

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