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Description
A very rare but serious allergic reaction that causes swelling of the face, tongue, and throat can occur
Endpoints included body weight, fat mass (NMR spectroscopy), glucose tolerance, and adipose-tissue NNMT enzymatic activity [1]

The FDA has recently made a public statement regarding Category 2 of bulk drug substances, focusing on Peptides

Drug Accumulation Whenever drug doses are repeated, the drug will accumulate in the body until dosing stops
