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Discussion 4.1

The average age of cardiomyopathy presentation is 2-4 years of age, indicating that it takes a long period of time for the manifestations of severe carnitine deficiency in the heart and skeletal muscle to appear

Similarly, a study conducted in Norway found no association between TMAO levels and carotid atherosclerosis or cardiovascular mortality [43]

These studies suggest that BMAds and their progenitor cells within the bone marrow niche generally suppress bone formation under normal or energy-excessive conditions
