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Glutathione came into the spotlight in clinical research, showing an enormous potential in prevention of deterioration of cartilage and inflammation , reduction of pain and improvement of mobility in patients, as well as promotion of regeneration of synovial tissue

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Therefore, reshaping the function of SGECs requires not only altering the local immune microenvironment but also improving the senescent phenotype, reducing inflammatory cell death of SGECs, and replenishing with newly regenerated parenchymal cells