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2024 (online 2023)

In the STEP 1 trial, once-weekly semaglutide 2.4 mg produced a mean weight loss of roughly 14.9% versus 2.4% for placebo over 68 weeks, establishing it as a benchmark anti-obesity agent
Animal studies administering 5-Amino-1MQ orally to diet-induced obese mice have shown dose-dependent reductions in body weight (typically 10-30% reduction compared to vehicle-treated obese controls over 4-12 week treatment periods), with the weight loss primarily reflecting fat mass reduction while lean mass is preserved or even increased