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The provider may decline to prescribe if health history includes contraindications (active cancer, pregnancy, nursing, certain metabolic conditions), medication interactions, or if submitted information raises clinical concerns
In an endothelium-independent way, CGRP, due to its receptors, causes adenylate cyclase activation and cAMP increase, which activates protein kinase A (PKA), and this, in turn, phosphorylates ATP-dependent K+ channels, which leads to Ca 2+ sequestration mechanisms and causes smooth muscle relaxation
doi: 10.1016/j.biopha.2024.116462 58 WangBLiJGaoHMXingYHLinZLiHJet al
