glutathione transferase and mapk pathway metabolic pathways. GCL, glutamate cysteine ligase; GST, Glutathione S-transferase pi expression regulates
Description
(2019) 31:e1904364
P21 Waf1/cip1 knockdown results in a complete cell cycle block in G1 phase, thus indicating that the garcinol-induced G1 block in H1299 cells is achieved by upregulation of p21 Waf1/cip1 protein expression
Figure 2 Interestingly, many of the initial studies elucidating NRF2-ARE-mediated cellular protection utilized tert -butyl hydroquinone (tBHQ), a synthetic antioxidant and inducer of the NRF2 pathway via its auto-oxidized, electrophilic form tert-butyl benzoquinone (tBQ) (Rushmore and Pickett, 1990
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