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In murine models of breast cancer, ICIE significantly transformed the TME from immunologically cold to hot by diminishing immunosuppressive cells (Tregs, M2-TAMs, MDSCs), augmenting the infiltration of CTLs, and elevating the CD 8+ /Treg ratio

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The peptide sequence of [desHis2, Leu3, desGly10]-LH-RH ethylamide, [desHis2, d-Ala6, desGly10]-LH-RH ethylamide and [desHis2, Leu3, D-Ala6, desGly10]-LH-RH ethylamide caused an inhibition of LH-RH-induced release of LH and FSH in rats 17

Integrin v3Targeted SLNs for Co-Delivery of Paclitaxel and Quercetin in Triple-Negative Breast Cancer