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Description
The activation of TFEB requires modification of a specific lysine residue in the translation initiation factor 5A (eIF-5A) generating what is called hypusine (derived from hy droxy pu trescine and ly sine ) which involves spermidine as outlined in the Polyamines in Protein Modification below
Clin Exp Hypertens A 9:11411157
Additionally, length of stay in hospital and ICU, vasopressor use, mechanical ventilation use, antimicrobial-related adverse outcomes, C
Conversely, periostin has been shown to activate NLRP3, promoting caspase-1-mediated pyroptosis in myocardial I/R injury [131]
