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Understanding the basic injury mechanisms of TBI requires testing experimental therapies on animals first to ensure their safety and effectiveness before moving on to human trials

Glossary CVDs cardiovascular diseases AI artificial intelligence CAD coronary artery disease WHO World Health Organization SEM scanning electron microscopy GWAS genome-wide association study PRS polygenic risk score HF heart failure HFPEF heart failure with preserved ejection fraction ECG electrocardiogram P4 medicine predictive, preventive, personalized, and participatory medicine ACNAP Association of Cardiovascular Nursing & Allied Professions CHF chronic heart failure EHR electronic health records PAH pulmonary arterial hypertension DCM dilated cardiomyopathy WGS whole-genome sequencing SNPs single-nucleotide polymorphisms scRNA-seq single-cell RNA sequencing HCM hypertrophic cardiomyopathy snRNA-seq single-nucleus RNA sequencing ACS acute coronary syndrome T2DM type 2 diabetes mellitus NLR neutrophil-to-lymphocyte ratio LVDD left ventricular diastolic dysfunction MI myocardial infarction MR Mendelian randomization DIA data-independent acquisition AMI acute myocardial infarction MVA malignant ventricular arrhythmia ASCVD atherosclerotic cardiovascular disease PPI protein-protein interaction KEGG Kyoto encyclopedia of genes and genomes GO gene ontology ML machine learning CNN convolutional neural network RNN recurrent neural network LVH left ventricular hypertrophy SEN sensitivity SPE specificity AI-QCT artificial intelligence-based quantitative coronary tomography CCTA coronary CT angiography QCA quantitative coronary angiography LLM large language model SVM support vector machine OPA occupational physical activity SES socioeconomic status PM2.5 particulate matter 2.5 micrometers or less in diameter R/S religious beliefs and spirituality NYHA New York Heart Association NO nitric oxide PTSD post-traumatic stress disorder DOH social determinants of health CAC coronary artery calcium

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