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KD ameliorated UC-induced intestinal barrier damage by inhibiting the overactivation of the PI3K/Akt/NF-B signaling pathway, attenuating the inflammatory response, including restoration of the intestinal villi and mitochondrial structure, and modulating the gut microbiota (increasing Alloprevotella , Treponema , Prevotella and Prevotellaceae , and decreasing Escherichia_Shigella and Desulfovibrio ) to optimize further the intestinal microenvironment (Liu et al., 2020)

Electrons (e) enter the chain via either Complex I or Complex II and are subsequently transferred to Complex III by ubiquinone (Coenzyme Q, CoQ), a mobile carrier often marketed as a health supplement despite its uncertain efficacy

14, Notes, Tables 15 and references

Specifically, the signaling pathways related to aldosterone synthesis and secretion, PI3K-Akt signaling pathway, ABC transporters, and Metabolic pathways showed significant enrichment of DEGs