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K.MohamedK.et al (2011b)

In addition, a study identified a positive feedback bistable ERN2-XBP1S pathway upregulated MUC5B mRNAs in IPF and further regulated mucus secretion, providing an unfolded protein response (UPR)-dependent mechanism with rs35705950 variant ( Environmental Environmental exposure and genetic predisposition may have a synergistic effect in the development of IPF (Figure 1)

doi: 10.1016/j.mucimm.2024.12.002 111 WestCMcVey NeufeldKA

Cytokines and growth factors Cytokines and growth factors are a large group of secreted proteins that stimulate intracellular communication to initiate cellular response via specific cell-surface receptors