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Treatment of BRAF V600E -mutant melanomas using mitogen-activated protein kinase inhibitors (MAPKi) induces tumor regression

This hypothesis from Wainwright et al

L-homoarginine, a non-protein amino acid, is synthesized from the catabolism of lysine or transamination of arginine in the small intestine, liver, and kidneys (Adams et al., 2019)
3.6 The three-dimensional crystal structure of MSA-DH To further investigate the molecular mechanism and cofactor utilization of MSA-DH, the X-ray protein structure was determined at 2.6 (data collection and refinement statistics in Supplementary Table S1)
