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doi: 10.2147/RRCC.S44465

Acknowledgements This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and University of Leicester funded Midlands Integrative Biosciences Training Partnership (MIBTP) [grant number BB/T00746X/1], and was funded in part, by the Wellcome Trust [Grant number 210911/Z/18/Z]

This study demonstrates that endothelial GR is critical to regulate the magnitude of the inflammatory process in response to LPS, and that glucocorticoid anti-inflammatory effects on the endothelium are mediated via GR repression of NF-B [81]

Given the conditions complexity, a multidisciplinary framework integrating dermatology, endocrinology, immunology, and pharmacology is essential