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These metabolic changes can limit the work capacity of skeletal muscle, since the accumulated acetyl-CoA inhibits the activity of pyruvate dehydrogenase [64]
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The inhibition of mitochondrial respiration leads to depolarization of the IMM, followed by the opening of the mPTP and activation of apoptosis [170]
Like with most restrictive diets, children and pregnant or breastfeeding women should also avoid keto unless otherwise instructed by their physicians
