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Currently, recommended treatments for local-regional CRCs include surgical resection, embolization to block the tumor blood supply, and radiotherapy (Young et al., 2014

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Research in brain-targeted delivery strategies and explore in natural products for BBB modulation have opened new avenues for effective CNS drug delivery

Consequently, signaling pathways such as mitogen-activated protein kinase (MAPK) signaling and tyrosine kinase activity were altered, leading to modulation of kinases and promoting aggressive breast cancer behavior