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Description
Reducing glutathione production in lymphoma cells, either through pharmacological inhibition of glutamate cysteine ligase (GCL), the enzyme catalyzing the rate-limiting step in glutathione biosynthesis, or via knockdown of GCLC, the GCL catalytic subunit, sharply decreased cell growth in 3D gels and xenografts
It is structurally designed to interact with metabolic enzyme pathways and has become a subject of interest in metabolic and mitochondrial research fields
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